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Serum remnant lipoprotein cholesterol/triglyceride ratio as an index for screening familial type III hyperlipidaemia.
- Source :
-
Annals of clinical biochemistry [Ann Clin Biochem] 2007 Jul; Vol. 44 (Pt 4), pp. 353-9. - Publication Year :
- 2007
-
Abstract
- Background: An elevated serum remnant lipoprotein cholesterol (RLP-C)/triglyceride (TG) ratio has not been evaluated as an index of familial type III hyperlipidaemia defined by the presence of beta-VLDL and apolipoprotein (Apo) E2/2 phenotype in the Japanese hyperlipidaemic population.<br />Methods: Serum lipids and lipoproteins from 514 individuals (200 men and 314 women, mean age 58 years) with total cholesterol >6.22 mmol/L and TG between 2.26 mmol/L and 9.04 mmol/L, selected from 25,080 subjects visiting the clinics for health checkup were analysed for a possible relationship with familial type III hyperlipoproteinaemia.<br />Results: Median RLP-C concentration and RLP-C/TG ratio were 0.30 and 0.11 mmol/L, respectively. When compared between subjects with (31 cases) and without (483 cases) a broad-beta band on electrophoresis, the RLP-C concentrations and RLP-C/TG ratio were 0.77 +/- 0.43 mmol/L versus 0.34 +/- 0.16 mmol/L (P<0.0001) and 0.15 +/- 0.023 versus 0.11 +/- 0.027 (P<0.0001), respectively. Three cases with broad-beta band positive (the presence of beta-VLDL) showed RLP-C/TG ratio greater than 0.23 and RLP-C greater than 0.78 mmol/L, suggestive of type III hyperlipoproteinaemia, despite a lack of characteristic Apo E2/2 homozygosity. Cases with Apo E/Apo CIII ratio greater than 1.0 were not detected in this study group.<br />Conclusion: Serum RLP-C concentration and RLP-C/TG ratio, together with Apo E/Apo CIII ratio appear to be useful for screening familial type III hyperlipidaemia in the Japanese hyperlipidaemic population.
- Subjects :
- Adolescent
Adult
Aged
Apolipoprotein C-III blood
Apolipoprotein E2 blood
Female
Humans
Hyperlipidemias blood
Hyperlipidemias diagnosis
Hyperlipoproteinemia Type III blood
Lipoproteins, IDL blood
Male
Mass Screening
Middle Aged
Apolipoproteins blood
Cholesterol blood
Hyperlipoproteinemia Type III diagnosis
Lipoproteins blood
Triglycerides blood
Subjects
Details
- Language :
- English
- ISSN :
- 0004-5632
- Volume :
- 44
- Issue :
- Pt 4
- Database :
- MEDLINE
- Journal :
- Annals of clinical biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 17663088
- Full Text :
- https://doi.org/10.1258/000456307780945787