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[Pathophysiology of kidney disease progression].
- Source :
-
Presse medicale (Paris, France : 1983) [Presse Med] 2007 Dec; Vol. 36 (12 Pt 2), pp. 1835-41. Date of Electronic Publication: 2007 Jul 25. - Publication Year :
- 2007
-
Abstract
- Nephron reduction increases the filtration capacity of the remaining nephrons, which is helpful in the short term, but harmful over the long term The increase in glomerular capillary pressure and in hypertrophy of healthy nephrons stimulates the renin-angiotensin system and TGF-beta. Myofibroblastic transdifferentiation follows, with fibrogenesis and glomerulosclerosis. Converting enzyme inhibitors reduce the expression of genes coding for profibrotic molecules. Proteinuria promotes interstitial fibrosis and must be reduced by drugs that block the renin-angiotensin system.
- Subjects :
- Angiotensin-Converting Enzyme Inhibitors pharmacology
Angiotensin-Converting Enzyme Inhibitors therapeutic use
Animals
Disease Progression
Fibrosis
Humans
Kidney pathology
Kidney Diseases metabolism
Nephrectomy
Proteinuria metabolism
Proteinuria prevention & control
Renin antagonists & inhibitors
Kidney Diseases physiopathology
Subjects
Details
- Language :
- French
- ISSN :
- 0755-4982
- Volume :
- 36
- Issue :
- 12 Pt 2
- Database :
- MEDLINE
- Journal :
- Presse medicale (Paris, France : 1983)
- Publication Type :
- Academic Journal
- Accession number :
- 17656061
- Full Text :
- https://doi.org/10.1016/j.lpm.2007.04.036