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Dietary Selenium for the counteraction of oxidative damage: fortified foods or supplements?
- Source :
-
The British journal of nutrition [Br J Nutr] 2008 Jan; Vol. 99 (1), pp. 191-7. Date of Electronic Publication: 2007 Jul 26. - Publication Year :
- 2008
-
Abstract
- Since any significant modification in the Se status, leading to changes in the activity of the seleno-enzymes, may have important consequences on the susceptibility of tissues to oxidative stress, considerable efforts have been made upon increasing Se dietary intake. In this respect, an important debate is still open about the bioavailability and the effectiveness of Se, and more generally nutrients, in supplements compared with foods. Using male Wistar rats, we have compared the effectiveness of two different diets in which an adequate Se content (0.1 mg/kg) was achieved by adding the element as sodium selenite or as component of a lyophilized Se-enriched food, in the counteraction of an oxidative stress induced by intraperitoneal administration of adriamycin. Both Se-enriched diets were able to reduce the consequences of the oxidative stress in liver, mainly by increasing glutathione peroxidase activity. This increase was more evident in rats fed on the diet enriched with the lyophilized food, probably due to the different chemical forms of Se, or to other components of the food itself. Although further studies are needed, data herein presented may contribute to the characterization of the effectiveness of Se from different sources, foods or supplements, in the light of dietary advice to the population concerning improvement of Se intake.
- Subjects :
- Animals
Antioxidants analysis
Biological Availability
Biomarkers blood
Dietary Supplements
Fatty Acids analysis
Glutathione analysis
Glutathione Peroxidase analysis
Glutathione Peroxidase blood
Lipids analysis
Lipids chemistry
Liver chemistry
Male
Oxidation-Reduction
Random Allocation
Rats
Rats, Wistar
Reactive Oxygen Species blood
Selenium blood
Sodium Selenite administration & dosage
Antioxidants administration & dosage
Food, Fortified
Liver metabolism
Selenium administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 0007-1145
- Volume :
- 99
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The British journal of nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 17651521
- Full Text :
- https://doi.org/10.1017/S0007114507793911