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Duration of untreated psychosis and neuropsychological function in first episode psychosis.
- Source :
-
Schizophrenia research [Schizophr Res] 2007 Sep; Vol. 95 (1-3), pp. 103-10. Date of Electronic Publication: 2007 Jul 20. - Publication Year :
- 2007
-
Abstract
- Purpose: We investigated whether duration of untreated psychosis (DUP) prior to first presentation was associated with cognitive function in first episode psychosis (FEP) subjects. We predicted that longer DUP would be associated with greater neurocognitive impairment.<br />Method: 180 subjects with schizophrenia (and 93 subjects with Other Psychoses) performed a neurocognitive battery assessing IQ, verbal learning, working memory, visual learning and speed of processing. DUP was defined as the number of days between first onset of psychotic symptoms and first contact with psychiatric services.<br />Results: Longer DUP was associated with impaired performance in verbal IQ (p=0.04), verbal learning (p=0.02), and verbal working memory (p=0.04) in FEP subjects with schizophrenia. These associations remained significant for verbal IQ when scores were corrected for age, gender, educational level and ethnicity.<br />Conclusions: Longer DUP is associated with poorer neurocognitive ability in schizophrenia subjects at time of first presentation. Since this was a cross-sectional study we can not tell whether longer DUP was a cause or a consequence of the poorer performance.
- Subjects :
- Adult
Age of Onset
Cognition Disorders psychology
Cross-Sectional Studies
Educational Status
Ethnicity statistics & numerical data
Female
Humans
Intelligence Tests statistics & numerical data
Male
Memory Disorders diagnosis
Memory Disorders psychology
Psychotic Disorders psychology
Reaction Time physiology
Schizophrenic Psychology
Verbal Learning physiology
Visual Perception physiology
Cognition Disorders diagnosis
Neuropsychological Tests statistics & numerical data
Psychotic Disorders diagnosis
Schizophrenia diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 0920-9964
- Volume :
- 95
- Issue :
- 1-3
- Database :
- MEDLINE
- Journal :
- Schizophrenia research
- Publication Type :
- Academic Journal
- Accession number :
- 17644343
- Full Text :
- https://doi.org/10.1016/j.schres.2007.05.037