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Use of anti-inflammatory drugs and lower esophageal sphincter-relaxing drugs and risk of esophageal and gastric cancers.
- Source :
-
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association [Clin Gastroenterol Hepatol] 2007 Oct; Vol. 5 (10), pp. 1154-1159.e3. Date of Electronic Publication: 2007 Jul 23. - Publication Year :
- 2007
-
Abstract
- Background & Aims: The incidence of esophageal and gastric cardia adenocarcinoma has increased in Western countries in recent decades for largely unknown reasons. We investigated whether use of LES-relaxing drugs was related to an increased risk of esophageal and gastric cardia adenocarcinoma, and whether use of NSAIDs was related to a reduced risk of esophageal and gastric cancers.<br />Methods: We examined these associations by using administrative databases in a case-control study in 2 integrated health care delivery systems. Cases were incident esophageal adenocarcinomas (n = 163) and squamous cell carcinomas (n = 114) and gastric cardia (n = 176) and non-cardia adenocarcinomas (n = 320), diagnosed between 1980-2002 in one health system and between 1993-2002 in the other. Matched controls (n = 3996) were selected. Complete prescription information was available for the study period.<br />Results: Prescription of corticosteroids was associated with a decreased risk of esophageal adenocarcinoma (odds ratio [OR], 0.6; 95% confidence interval [CI], 0.4-0.9), esophageal squamous cell carcinoma (OR, 0.4; 95% CI, 0.2-0.6), and gastric non-cardia carcinoma (OR, 0.4, 95% CI, 0.3-0.6). Ever use of pharmacy-purchased aspirin was associated with 30%-60% decreased risks of the studied cancers. As a group, LES-relaxing drugs showed little evidence of association with increased risk of any esophageal or gastric cancer.<br />Conclusions: Corticosteroid and aspirin use were associated with significantly decreased risks of esophageal and gastric cancer. LES-relaxing drugs as a group did not affect these risks, although we had limited power to assess individual drugs. The possibility that corticosteroids and aspirin might reduce esophageal cancer risk warrants further consideration.
- Subjects :
- Adenocarcinoma chemically induced
Adenocarcinoma epidemiology
Adenocarcinoma pathology
Aged
Carcinoma, Squamous Cell chemically induced
Carcinoma, Squamous Cell epidemiology
Carcinoma, Squamous Cell pathology
Esophageal Neoplasms epidemiology
Esophageal Neoplasms pathology
Esophagus drug effects
Female
Follow-Up Studies
Humans
Incidence
Male
Odds Ratio
Retrospective Studies
Risk Factors
Stomach Neoplasms epidemiology
Stomach Neoplasms pathology
United States epidemiology
Anti-Inflammatory Agents, Non-Steroidal adverse effects
Antidepressive Agents adverse effects
Esophageal Neoplasms chemically induced
Esophagus physiopathology
Histamine H1 Antagonists adverse effects
Muscle Contraction drug effects
Stomach Neoplasms chemically induced
Subjects
Details
- Language :
- English
- ISSN :
- 1542-7714
- Volume :
- 5
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
- Publication Type :
- Academic Journal
- Accession number :
- 17644046
- Full Text :
- https://doi.org/10.1016/j.cgh.2007.05.022