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Risk factors for rate of decline in forced expiratory volume in one second in children and adolescents with cystic fibrosis.
Risk factors for rate of decline in forced expiratory volume in one second in children and adolescents with cystic fibrosis.
- Source :
-
The Journal of pediatrics [J Pediatr] 2007 Aug; Vol. 151 (2), pp. 134-9, 139.e1. Date of Electronic Publication: 2007 Jun 22. - Publication Year :
- 2007
-
Abstract
- Objectives: To characterize the rate of decline of forced expiratory volume in 1 second (FEV(1)) in children and adolescents with cystic fibrosis and to identify and compare risk factors associated with FEV(1) decline.<br />Study Design: The rate of decline in FEV(1)% predicted over 3 to 6 years in 3 different age groups was determined. Risk factors for decline were identified and compared among and within age groups as a function of disease severity with repeated-measures, mixed-model regression.<br />Results: Mean (+/-SD) baseline FEV(1)% predicted was 88.4% +/- 20.5% for 6- to 8-year-olds (n = 1811), 85.3% +/- 20.8% for 9- to 12-year-olds (n = 1696), and 78.4% +/- 22.0% for 13- to 17-year-olds (n = 1359). Decline in FEV(1)% predicted/year was -1.12, -2.39, and -2.34, respectively. High baseline FEV(1) and persistent crackles were significant independent risk factors for decline across all age groups. Female sex, Pseudomonas aeruginosa infection, low weight-for-age, sputum, wheezing, sinusitis, pulmonary exacerbations treated with intravenous antibiotics, elevated liver test results, and pancreatic insufficiency were also identified as independent risk factors in some age groups.<br />Conclusions: This study identifies risk factors for FEV(1) decline in children and adolescents with cystic fibrosis. Clinicians should not be reassured by high lung function, particularly in young children, because this factor, among others, is independently associated with steeper decline in FEV(1).
- Subjects :
- Adolescent
Age Distribution
Child
Cohort Studies
Disease Progression
Female
Humans
Incidence
Lung Diseases diagnosis
Male
Prognosis
Risk Factors
Severity of Illness Index
Sex Distribution
Spirometry methods
Time Factors
Vital Capacity
Cystic Fibrosis diagnosis
Cystic Fibrosis epidemiology
Forced Expiratory Volume
Lung Diseases epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6833
- Volume :
- 151
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The Journal of pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 17643762
- Full Text :
- https://doi.org/10.1016/j.jpeds.2007.03.006