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Ovariectomy is protective against renal injury in the high-salt-fed older mRen2. Lewis rat.
- Source :
-
American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2007 Oct; Vol. 293 (4), pp. H2064-71. Date of Electronic Publication: 2007 Jul 13. - Publication Year :
- 2007
-
Abstract
- Studies in experimental animals and younger women suggest a protective role for estrogen; however, clinical trials may not substantiate this effect in older females. Therefore, the present study assessed the outcome of ovariectomy in older mRen2. Lewis rats subjected to a high-salt diet for 4 wk. Intact or ovariectomized (OVX, 15 wk of age) mRen2. Lewis rats were aged to 60 wk and then placed on a high-salt (HS, 8% sodium chloride) diet for 4 wk. Systolic blood pressures were similar between groups [OVX 169 +/- 6 vs. Intact 182 +/- 7 mmHg; P = 0.22] after the 4-wk diet; however, proteinuria [OVX 0.8 +/- 0.2 vs. Intact 11.5 +/- 2.6 mg/mg creatinine; P < 0.002, n = 6], renal interstitial fibrosis, glomerular sclerosis, and tubular casts were lower in OVX vs. Intact rats. Kidney injury molecule-1 mRNA, a marker of tubular damage, was 53% lower in the OVX HS group. Independent from blood pressure, OVX HS rats exhibited significantly lower cardiac (24%) and renal (32%) hypertrophy as well as lower C-reactive protein (28%). Circulating insulin-like growth factor-I (IGF-I) levels were not different between the Intact and OVX groups; however, renal cortical IGF-I mRNA and protein were attenuated in OVX rats [P < 0.05, n = 6]. We conclude that ovariectomy in the older female mRen2. Lewis rat conveys protection against salt-dependent increase in renal injury.
- Subjects :
- Aging metabolism
Angiotensin I metabolism
Angiotensin II metabolism
Animals
Animals, Congenic
C-Reactive Protein metabolism
Cell Adhesion Molecules genetics
Cell Adhesion Molecules metabolism
Disease Models, Animal
Female
Fibrosis
Hypertension etiology
Hypertension genetics
Hypertension metabolism
Hypertension physiopathology
Hypertrophy
Insulin-Like Growth Factor I genetics
Insulin-Like Growth Factor I metabolism
Intracellular Signaling Peptides and Proteins genetics
Intracellular Signaling Peptides and Proteins metabolism
Kidney pathology
Kidney physiopathology
Kidney Diseases etiology
Kidney Diseases metabolism
Kidney Diseases physiopathology
Membrane Proteins genetics
Membrane Proteins metabolism
Peptide Fragments metabolism
Proteinuria etiology
Proteinuria metabolism
Proteinuria physiopathology
Proteinuria prevention & control
RNA, Messenger metabolism
Rats
Rats, Inbred Lew
Renin genetics
Renin-Angiotensin System
Sodium Chloride, Dietary
Blood Pressure
Hypertension complications
Kidney metabolism
Kidney Diseases prevention & control
Ovariectomy
Renin metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0363-6135
- Volume :
- 293
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- American journal of physiology. Heart and circulatory physiology
- Publication Type :
- Academic Journal
- Accession number :
- 17630347
- Full Text :
- https://doi.org/10.1152/ajpheart.00427.2007