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[Dysregulation of Annexin II expression in esophageal squamous cell cancer and adjacent tissues from a high-incidence area for esophageal cancer in Henan province].
- Source :
-
Ai zheng = Aizheng = Chinese journal of cancer [Ai Zheng] 2007 Jul; Vol. 26 (7), pp. 730-6. - Publication Year :
- 2007
-
Abstract
- Background & Objective: Our recent study on proteomics for esophageal cancer has indicated the importance of Annexin II as a promising protein to distinguish esophageal cancer patients from healthy subjects. This study was to detect the expression of Annexin II in esophageal squamous cell carcinoma (ESCC) and adjacent tissues, and to explore the role of Annexin II in ESCC pathogenesis and mechanisms.<br />Methods: The expression of Annexin I in 33 specimens of ESCC and adjacent tissues from Linzhou, a high-incidence area for esophageal cancer in Henan province, was detected by ABC immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR).<br />Results: Annexin II protein was expressed in 90.6% normal esophageal epithelium and decreased with ESCC progression. In carcinoma in situ (CIS), 50.0% foci lost Annexin II protein expression. The expression of Annexin II protein was increased in well differentiated SCC and decreased with loss of differentiation of SCC. In poorly differentiated SCC, 45.4% foci lost Annexin II protein expression. However, RT-PCR did not detect differential expression of Annexin II mRNA between normal esophageal epithelium and CIS.<br />Conclusions: Elevated or reduced expression of Annexin II may be correlated to reverse or progression of carcinogenesis respectively, and Annexin II may be another candidate biomarker for screening of high-risk subjects and early diagnosis of SCC.
- Subjects :
- Adult
Aged
Annexin A2 genetics
Carcinoma in Situ epidemiology
Carcinoma in Situ metabolism
Carcinoma in Situ pathology
Carcinoma, Squamous Cell epidemiology
Carcinoma, Squamous Cell pathology
Cell Differentiation
China epidemiology
Epithelial Cells metabolism
Esophageal Neoplasms epidemiology
Esophageal Neoplasms pathology
Esophagus metabolism
Female
Humans
Immunohistochemistry
Incidence
Male
Middle Aged
Precancerous Conditions metabolism
Precancerous Conditions pathology
RNA, Messenger metabolism
Reverse Transcriptase Polymerase Chain Reaction
Annexin A2 biosynthesis
Carcinoma, Squamous Cell metabolism
Esophageal Neoplasms metabolism
Subjects
Details
- Language :
- Chinese
- Volume :
- 26
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Ai zheng = Aizheng = Chinese journal of cancer
- Publication Type :
- Academic Journal
- Accession number :
- 17626749