Back to Search
Start Over
JAM-C regulates unidirectional monocyte transendothelial migration in inflammation.
- Source :
-
Blood [Blood] 2007 Oct 01; Vol. 110 (7), pp. 2545-55. Date of Electronic Publication: 2007 Jul 11. - Publication Year :
- 2007
-
Abstract
- Monocyte recruitment from the vasculature involves sequential engagement of multiple receptors, culminating in transendothelial migration and extravasation. Junctional adhesion molecule-C (JAM-C) is localized at endothelial intercellular junctions and plays a role in monocyte transmigration. Here, we show that blockade of JAM-B/-C interaction reduced monocyte numbers in the extravascular compartment through increased reverse transmigration rather than by reduced transmigration. This was confirmed in vivo, showing that an anti-JAM-C antibody reduced the number of monocytes in inflammatory tissue and increased the number of monocytes with a reverse-transmigratory phenotype in the peripheral blood. All together, our results suggest a novel mechanism of reducing accumulation of monocytes at inflammation sites by disruption of JAM-C-mediated monocyte retention.
- Subjects :
- Animals
Antibodies immunology
Blood Platelets metabolism
Cell Adhesion
Cell Adhesion Molecules genetics
Cell Adhesion Molecules immunology
Cells, Cultured
Endothelial Cells metabolism
Humans
Inflammation metabolism
Inflammation pathology
Junctional Adhesion Molecules
Mice
Mice, Transgenic
Phenotype
Cell Adhesion Molecules metabolism
Cell Movement
Monocytes cytology
Monocytes metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0006-4971
- Volume :
- 110
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Blood
- Publication Type :
- Academic Journal
- Accession number :
- 17625065
- Full Text :
- https://doi.org/10.1182/blood-2007-03-078733