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Impact of genetic polymorphisms on the risk of lipid disorders in patients on anti-HIV therapy.
- Source :
-
Clinical chemistry and laboratory medicine [Clin Chem Lab Med] 2007; Vol. 45 (7), pp. 815-21. - Publication Year :
- 2007
-
Abstract
- Active anti-HIV therapy can induce hypertriglyceridemia, low high-density lipoprotein (HDL) and insulin resistance, eventually accompanied by clinical lipodystrophy, associated loss of subcutaneous adipose tissue and an increase in abdominal adiposity. The frequency of these metabolic disorders is approximately 50% and host genetic factors might confer particular susceptibility. Variants of apolipoproteins (apo) A5 and C3, interacting with APOE genotypes, have been associated with the severity of antiretroviral therapy-induced dyslipidemia and with occurrence of lipodystrophy, and for APOC3, with objective criteria of fat redistribution. Genetic polymorphisms of the nuclear transcription-factor sterol response element-binding proteins (SREBP1c) and of tumor necrosis factor-alpha (TNFalpha) have yielded contrasting results. Other candidate genes will be explored to define a pharmacogenomic strategy to identify patients at high risk of metabolic disorders upon antiretroviral therapy.
- Subjects :
- Antiretroviral Therapy, Highly Active adverse effects
Apolipoproteins genetics
Apolipoproteins metabolism
Genetic Predisposition to Disease
Genotype
HIV Infections drug therapy
HIV Infections genetics
HIV-Associated Lipodystrophy Syndrome genetics
Humans
Lipid Metabolism Disorders genetics
Sterol Regulatory Element Binding Protein 1 genetics
Tumor Necrosis Factor-alpha genetics
HIV Protease Inhibitors adverse effects
HIV-Associated Lipodystrophy Syndrome chemically induced
Lipid Metabolism Disorders chemically induced
Polymorphism, Genetic
Subjects
Details
- Language :
- English
- ISSN :
- 1434-6621
- Volume :
- 45
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Clinical chemistry and laboratory medicine
- Publication Type :
- Academic Journal
- Accession number :
- 17617020
- Full Text :
- https://doi.org/10.1515/CCLM.2007.140