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Human maxillary tuberosity and jaw periosteum as sources of osteoprogenitor cells for tissue engineering.

Human maxillary tuberosity and jaw periosteum as sources of osteoprogenitor cells for tissue engineering.

Authors :
Cicconetti A
Sacchetti B
Bartoli A
Michienzi S
Corsi A
Funari A
Robey PG
Bianco P
Riminucci M
Source :
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics [Oral Surg Oral Med Oral Pathol Oral Radiol Endod] 2007 Nov; Vol. 104 (5), pp. 618.e1-12. Date of Electronic Publication: 2007 Jul 05.
Publication Year :
2007

Abstract

Objective: Bone tissue engineering is a promising approach for bone reconstruction in oral-maxillofacial surgery. This study investigates the suitability of oral skeletal tissues as convenient and accessible sources of osteogenic progenitors as an alternative to the iliac crest bone marrow.<br />Study Design: Samples of maxilla tuberosity (MT) and maxillary and mandibular periosteum (MP) were obtained during routine oral surgery, and donor site morbidity was assessed using a "split-mouth" approach. Cells isolated from MT (bone marrow stromal cells; MT-BMSCs) and from MP (periosteal cells; M-PCs), were analyzed for clonogenicity, phenotype, expression of osteogenic markers, and ability to form bone in vivo.<br />Results: Both MT-BMSCs and M-PCs included clonogenic cells, showed comparable phenotypic profiles, and expressed early osteogenic markers. Most importantly, both cell populations formed bone upon ectopic in vivo transplantation.<br />Conclusion: MT-BMSCs and M-PCs behaved as osteoprogenitor cells in vitro and in vivo. MT and MP may be considered as suitable sources of cells for bone tissue engineering in humans.

Details

Language :
English
ISSN :
1528-395X
Volume :
104
Issue :
5
Database :
MEDLINE
Journal :
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
Publication Type :
Academic Journal
Accession number :
17613258
Full Text :
https://doi.org/10.1016/j.tripleo.2007.02.022