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Short and efficient total synthesis of luotonin A and 22-hydroxyacuminatine using a common cascade strategy.
- Source :
-
The Journal of organic chemistry [J Org Chem] 2007 Aug 03; Vol. 72 (16), pp. 6270-2. Date of Electronic Publication: 2007 Jul 04. - Publication Year :
- 2007
-
Abstract
- Total syntheses of 22-hydroxyacuminatine and luotonin A were achieved in direct fashion and high overall yields (16% in eight steps and 47% in five steps, respectively). A mild cascade methodology was successfully applied in both syntheses as a common strategy. The new approach presents the advantages of short routes, high overall yields, use of stable intermediates, and ease of operations.
- Subjects :
- Camptothecin chemistry
Fluorenes chemistry
Indolizines chemistry
Models, Chemical
Molecular Conformation
Pyrroles chemistry
Quinolines chemistry
Quinones chemistry
Chemistry, Organic methods
Indolizines chemical synthesis
Pyrroles chemical synthesis
Quinolines chemical synthesis
Quinones chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0022-3263
- Volume :
- 72
- Issue :
- 16
- Database :
- MEDLINE
- Journal :
- The Journal of organic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 17608538
- Full Text :
- https://doi.org/10.1021/jo070837d