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Successful outcome of severe adenovirus hepatitis of the allograft following liver transplantation.
- Source :
-
Transplant infectious disease : an official journal of the Transplantation Society [Transpl Infect Dis] 2007 Dec; Vol. 9 (4), pp. 318-22. Date of Electronic Publication: 2007 Jul 01. - Publication Year :
- 2007
-
Abstract
- Here we report the first adult patient who survived severe adenoviral hepatitis of a liver graft, in contrast to 4 previously reported cases in adults, all of which had a fatal outcome. Early diagnosis was based on the immunohistological detection of adenoviral protein in the context of biopsy-proven hepatitis. Dramatic reduction of immunosuppression along with supportive care were the treatment strategies in this case. Adenoviral infection of the allograft should always be considered as a differential diagnosis when clinical signs of severe hepatitis are present after liver transplantation. Accurate diagnosis with immunohistochemical detection of viral proteins in the liver graft is of paramount importance for the early diagnosis and management of this uncommon, severe, and probably underdiagnosed entity.
- Subjects :
- Adenovirus Infections, Human diagnosis
Adenovirus Infections, Human drug therapy
Adult
Hepatitis, Viral, Human diagnosis
Hepatitis, Viral, Human drug therapy
Humans
Immunocompromised Host
Male
Prednisone administration & dosage
Transplantation, Homologous
Treatment Outcome
Adenovirus Infections, Human virology
Hepatitis, Viral, Human virology
Liver virology
Liver Transplantation adverse effects
Transplants virology
Subjects
Details
- Language :
- English
- ISSN :
- 1398-2273
- Volume :
- 9
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Transplant infectious disease : an official journal of the Transplantation Society
- Publication Type :
- Academic Journal
- Accession number :
- 17605750
- Full Text :
- https://doi.org/10.1111/j.1399-3062.2007.00205.x