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Micropumps, microvalves, and micromixers within PCR microfluidic chips: Advances and trends.
- Source :
-
Biotechnology advances [Biotechnol Adv] 2007 Sep-Oct; Vol. 25 (5), pp. 483-514. Date of Electronic Publication: 2007 May 23. - Publication Year :
- 2007
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Abstract
- This review surveys the advances of microvalves, micropumps, and micromixers within PCR microfluidic chips over the past ten years. First, the types of microvalves in PCR chips are discussed, including active and passive microvalves. The active microvalves are subdivided into mechanical (thermopneumatic and shape memory alloy), non-mechanical (hydrogel, sol-gel, paraffin, and ice), and external (modular built-in, pneumatic, and non-pneumatic) microvalves. The passive microvalves also include mechanical (in-line polymerized gel and passive plug) and non-mechanical (hydrophobic) microvalves. The review then discusses mechanical (piezoelectric, pneumatic, and thermopneumatic) and non-mechanical (electrokinetic, magnetohydrodynamic, electrochemical, acoustic-wave, surface tension and capillary, and ferrofluidic magnetic) micropumps in PCR chips. Next, different micromixers within PCR chips are presented, including passive (Y/T-type flow, recirculation flow, and drop) and active (electrokinetically-driven, acoustically-driven, magnetohydrodynamical-driven, microvalves/pumps) micromixers. Finally, general discussions on microvalves, micropumps, and micromixers for PCR chips are given. The microvalve/micropump/micromixers allow high levels of PCR chip integration and analytical throughput.
- Subjects :
- Electrochemistry methods
Equipment Design
Flow Injection Analysis methods
Kinetics
Microchemistry methods
Microfluidic Analytical Techniques methods
Microfluidics methods
Nanotechnology methods
Polymerase Chain Reaction methods
Microchemistry instrumentation
Microfluidic Analytical Techniques instrumentation
Microfluidics instrumentation
Polymerase Chain Reaction instrumentation
Subjects
Details
- Language :
- English
- ISSN :
- 0734-9750
- Volume :
- 25
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Biotechnology advances
- Publication Type :
- Academic Journal
- Accession number :
- 17601695
- Full Text :
- https://doi.org/10.1016/j.biotechadv.2007.05.003