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Effects of Botox and Neuronox on muscle force generation in mice.

Authors :
Stone AV
Ma J
Whitlock PW
Koman LA
Smith TL
Smith BP
Callahan MF
Source :
Journal of orthopaedic research : official publication of the Orthopaedic Research Society [J Orthop Res] 2007 Dec; Vol. 25 (12), pp. 1658-64.
Publication Year :
2007

Abstract

The current study determined the dose-response relationship for inhibition of muscle force of two commercially available botulinum neurotoxin type-A (BoNTA) preparations (Botox and Neuronox) in a murine model and characterized the time course of recovery from the toxin-induced muscle paralysis. The effect of freezing reconstituted toxin on toxin potency was also determined. The gastrocnemius muscles in male CD-1 mice were injected with either saline or BoNTA (0.3-3.0 U/kg), and muscle force generation was examined following stimulation of the tibial nerve (single twitch and 15-200 Hz tetany). Botox and Neuronox produced nearly equivalent decrements in muscle force (30%-90%) at 4 days after toxin injection. At 28 days after injection (1 U/kg), muscle force had recovered from the effects of both toxin preparations. Maintaining reconstituted toxin at -80 degrees C for up to 5 months did not result in significant loss of toxin activity. The results of this study suggest that Botox and Neuronox produce equivalent responses in a murine model, and, in contrast to other models, muscle recovery is rapid with doses of toxin that produce less than maximal decrements in muscle force.<br /> (Copyright 2007 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.)

Details

Language :
English
ISSN :
1554-527X
Volume :
25
Issue :
12
Database :
MEDLINE
Journal :
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Publication Type :
Academic Journal
Accession number :
17600825
Full Text :
https://doi.org/10.1002/jor.20450