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Effect of clentiazem on lipid profile, lipoprotein composition and aortic fatty streaks in cholesterol-fed rabbits.
- Source :
-
Atherosclerosis [Atherosclerosis] 1991 Oct; Vol. 90 (2-3), pp. 141-8. - Publication Year :
- 1991
-
Abstract
- Numerous experimental studies have reported that common antihypertensive drugs such as diuretics, beta-blockers, and methyldopa have adverse effects on plasma lipids and lipoproteins. The present study was designed to define the effect of clentiazem (10 mg/kg/day) an antihypertensive drug, on hyperlipidemia in rabbits on a cholesterol-rich diet (1%) for 12 weeks. Compared with controls, clentiazem treated rabbits had lower plasma concentrations of triglycerides (55%), total cholesterol (24%), free cholesterol (27%), esterified cholesterol (23%) and phospholipids (24%). The decrease in cholesterol was accounted for by a reduction of VLDL-cholesterol (13%), IDL-cholesterol (24%) and primarily LDL-cholesterol (45%). Neither HDL-cholesterol nor chemical composition of VLDL, IDL, LDL and HDL was altered. When the aortic atherosclerotic involvement was evaluated by computerized planimetry, a 24% reduction of lesions was noted in clentiazem treated animals (P less than 0.05). Similarly, cholesterol content extracted from aortic wall was decreased. Our data therefore demonstrated that clentiazem is a potential antiatherosclerotic agent capable of decreasing plasma lipids and atherogenic lipoproteins as well as aortic fatty streaks.
- Subjects :
- Animals
Aorta metabolism
Aorta pathology
Aortic Diseases metabolism
Aortic Diseases pathology
Arteriosclerosis metabolism
Arteriosclerosis pathology
Cholesterol blood
Diltiazem pharmacology
Lipid Metabolism
Male
Rabbits
Triglycerides blood
Antihypertensive Agents pharmacology
Aortic Diseases blood
Arteriosclerosis blood
Cholesterol, Dietary administration & dosage
Diltiazem analogs & derivatives
Lipids blood
Lipoproteins chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0021-9150
- Volume :
- 90
- Issue :
- 2-3
- Database :
- MEDLINE
- Journal :
- Atherosclerosis
- Publication Type :
- Academic Journal
- Accession number :
- 1759985
- Full Text :
- https://doi.org/10.1016/0021-9150(91)90108-f