[Normalizing effect of intermittent hypoxic training on the function of endothelium in experimental diabetes mellitus].

The purpose of the study was to investigate changes of endothelial function at experimental diabetes mellitus under the action of interval hypoxic trainings (IHT). A decrease of hyperglycemia and normalization of endothelium-dependent vascular reactions are shown after IHT. Activity of constitutive NOS in the heart after IHT increases considerably while activity of inducible NOS decreases sharply. Considerable diminution of iNOS activity after IHT also registered in aorta. Nitrite-anion content (NO2-) increased both in the heart and in aorta. IHT results in diminishing level of such markers of oxidizing stress as a hydrogen peroxide and dien conjugates. Thus, the action of IHT consist in diminishing ofhyperglycemia, decline of expressed of oxidizing stress, partial normalization of synthesis of nitric oxide and renewal of endothelial function in rats with experimental diabetes.