Synthesis and in vitro antiproliferative activity of new 1,3-(oxytetraethylenoxy)-cyclotriphosphazene derivatives.

A new series of 1,3-(oxytetraethylenoxy)-cyclotriphosphazene derivatives containing aziridine or salicylaldehyde (2-hydroxybenzaldehyde) or its Schiff base units after condensation with 2-chloroethylamine and anthraquinone groups as co-substituents has been synthesized. Their cytostatic activity in vitro against the HL-60, A549 and HCV29T cancer cell lines has been studied. Some of the compounds exhibited antiproliferative activity in the range of the international criteria for synthetic agents (4 microg/ml) against the cell lines being tested.