Back to Search
Start Over
Isolation of two bioactive ent-kauranoids from the leaves of Isodon xerophilus.
- Source :
-
Journal of agricultural and food chemistry [J Agric Food Chem] 2007 Jul 25; Vol. 55 (15), pp. 6039-43. Date of Electronic Publication: 2007 Jun 27. - Publication Year :
- 2007
-
Abstract
- Isodon xerophilus has been used as a herbal cold tea for the prevention and treatment of sore throat and inflammation in southernwestern China. A phytochemical study on the ethyl acetate (EtOAc) soluble fraction of I. xerophilus leaves led to the isolation of two new ent-kauranoids, xerophinoids A (1) and B (2), together with 14 known diterpenoids. The structures of xerophinoids A (1) and B (2) were illustrated using spectroscopic methods including 1D and 2D NMR analyses. To study their biological activities, the effects of xerophinoids A (1) and B (2) on nitrite production, tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta were examined. In addition, xerophinoids A (1) and B (2) also exhibited potent cytotoxicity against several human tumor cell lines (IC50 < 11 microM), but they had no toxicity on human T-lymphocyte (C8166).
- Subjects :
- Animals
Antineoplastic Agents, Phytogenic pharmacology
Cell Death drug effects
Cell Line, Tumor
Diterpenes, Kaurane chemistry
Diterpenes, Kaurane pharmacology
Humans
Models, Molecular
Molecular Structure
Rats
Diterpenes, Kaurane isolation & purification
Isodon chemistry
Plant Leaves chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0021-8561
- Volume :
- 55
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Journal of agricultural and food chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 17595108
- Full Text :
- https://doi.org/10.1021/jf070734w