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Antidyslipidemic activity of Indigofera tinctoria.
- Source :
-
Journal of herbal pharmacotherapy [J Herb Pharmacother] 2007; Vol. 7 (1), pp. 59-64. - Publication Year :
- 2007
-
Abstract
- Indigofera tinctoria is a perennial shrub, which belongs to the family Papilionaceae. As a part of our drug discovery program we have investigated the antidyslipidemic activity of the alcoholic extract from Indigofera tinctoria as well as its three other components, that is, chloroform, butanol and aqueous fractions in dyslipidemic hamsters that were fed a high fat diet. The chloroform fraction showed a significant decrease in the plasma triglycerides (TG, 52%) (P < 0.001), total cholesterol (TC, 29%) (P < 0.05), glycerol (Gly, 24%) and free fatty acids (FFA, 14%). This decrease was also accompanied by an increase in high density lipoproteins (HDL) by 9% and an increased HDL-C/TC ratio of 52% at the dose of 250 mg/kg of body weight.
- Subjects :
- Administration, Oral
Animals
Butanols chemistry
Chloroform chemistry
Cholesterol metabolism
Cholesterol Esters metabolism
Cholesterol, LDL metabolism
Cricetinae
Dietary Fats
Dose-Response Relationship, Drug
Glycerol metabolism
Hypolipidemic Agents chemistry
Hypolipidemic Agents isolation & purification
Lipoproteins, HDL metabolism
Male
Plant Extracts administration & dosage
Plants, Medicinal chemistry
Triglycerides metabolism
Butanols administration & dosage
Chloroform administration & dosage
Hypolipidemic Agents administration & dosage
Indigofera chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1522-8940
- Volume :
- 7
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of herbal pharmacotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 17594987
- Full Text :
- https://doi.org/10.1300/j157v07n01_05