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Neuroinflammation in Parkinson's patients and MPTP-treated mice is not restricted to the nigrostriatal system: microgliosis and differential expression of interleukin-1 receptors in the olfactory bulb.
- Source :
-
Experimental gerontology [Exp Gerontol] 2007 Aug; Vol. 42 (8), pp. 762-71. Date of Electronic Publication: 2007 Apr 29. - Publication Year :
- 2007
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Abstract
- Neuroinflammation may play a role in the pathogenesis of Parkinson's disease (PD). The present study questioned whether this neuroinflammatory response differs between the olfactory bulb, as an early affected region and the nigrostriatal system. Indeed, increased microgliosis was shown in post-mortem olfactory bulb of PD patients. Also in olfactory bulb of MPTP-treated mice, microgliosis and increased expression of IL-1alpha, IL-1beta and IL-1ra mRNA was observed early after treatment. These observations implicate that neuroinflammation is not restricted to the nigrostriatal system. MPTP-induced microgliosis in striatum and olfactory bulb was reduced in IL-1alpha/beta knockout mice, indicating that IL-1 affects microglia activation. Importantly, MPTP induced differential regulation of IL-1 receptors. mRNA levels of IL-1RI and, to a lesser extent, IL-1RII were increased in striatum. Interestingly, in the olfactory bulb only IL-1RII mRNA was enhanced. We suggest that differential regulation of IL-1 signaling can serve as an important mechanism to modulate neuroinflammatory activity after MPTP treatment and possibly during PD.
- Subjects :
- Animals
Base Sequence
Corpus Striatum drug effects
Corpus Striatum immunology
Corpus Striatum pathology
DNA Primers genetics
Gene Expression
Humans
MPTP Poisoning genetics
Male
Mice
Mice, Inbred C57BL
Microglia drug effects
Microglia pathology
Olfactory Bulb drug effects
Parkinson Disease genetics
Parkinsonian Disorders genetics
Receptors, Interleukin-1 classification
Substantia Nigra drug effects
Substantia Nigra immunology
Substantia Nigra pathology
MPTP Poisoning immunology
MPTP Poisoning pathology
Olfactory Bulb immunology
Olfactory Bulb pathology
Parkinson Disease immunology
Parkinson Disease pathology
Parkinsonian Disorders immunology
Parkinsonian Disorders pathology
Receptors, Interleukin-1 genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0531-5565
- Volume :
- 42
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Experimental gerontology
- Publication Type :
- Academic Journal
- Accession number :
- 17592750
- Full Text :
- https://doi.org/10.1016/j.exger.2007.04.010