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Growth hormone (GH) secretion and response to GH therapy after total body irradiation and haematopoietic stem cell transplantation during childhood.
- Source :
-
Clinical endocrinology [Clin Endocrinol (Oxf)] 2007 Oct; Vol. 67 (4), pp. 589-97. Date of Electronic Publication: 2007 Jun 21. - Publication Year :
- 2007
-
Abstract
- Objective: In January 1997 we introduced a protocol for the treatment with GH of children with impaired growth after unfractionated total body irradiation (TBI). This study is an evaluation of that protocol.<br />Patients and Methods: Between January 1997 and July 2005, 66 patients (48 male) treated for haematological malignancies had at least two years of disease-free survival after TBI-based conditioning for stem cell transplantation (SCT). Stimulated and/or spontaneous GH secretion was decreased in 8 of the 29 patients tested because of impaired growth. Treatment with GH (daily dose 1.3 mg/m2 body surface area) was offered to all 29 patients and initiated in 23 of them (17 male). The main outcome measure was the effect of GH therapy on height standard deviation scores (SDS) after onset of GH therapy, estimated by random-effect modelling with corrections for sex, age at time of SCT and puberty (data analysed on intention-to-treat basis).<br />Results: At time of analysis, median duration of therapy was 3.2 years; median follow-up after start of GH therapy was 4.2 years. The estimated effect of GH therapy, modelled as nonlinear (logit) curve, was +1.1 SD after 5 years. Response to GH therapy did not correlate to GH secretion status.<br />Conclusion: GH therapy has a positive effect on height SDS after TBI, irrespective of GH secretion status.
- Subjects :
- Adolescent
Body Height drug effects
Carcinoma, Papillary diagnosis
Child
Female
Follow-Up Studies
Growth Disorders blood
Growth Disorders etiology
Growth Hormone deficiency
Hematologic Neoplasms therapy
Humans
Male
Osteosarcoma diagnosis
Thyroid Neoplasms diagnosis
Transplantation Conditioning
Growth Disorders drug therapy
Growth Hormone blood
Hematopoietic Stem Cell Transplantation
Hormone Replacement Therapy adverse effects
Human Growth Hormone therapeutic use
Whole-Body Irradiation
Subjects
Details
- Language :
- English
- ISSN :
- 0300-0664
- Volume :
- 67
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Clinical endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 17590170
- Full Text :
- https://doi.org/10.1111/j.1365-2265.2007.02930.x