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The glutathione thiyl radical does not react with nitrogen monoxide.

Authors :
Hofstetter D
Nauser T
Koppenol WH
Source :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2007 Aug 17; Vol. 360 (1), pp. 146-8. Date of Electronic Publication: 2007 Jun 11.
Publication Year :
2007

Abstract

Laser flash photolysis experiments shows that the rate constant for the reaction of the glutathione thiyl radical with nitrogen monoxide to give S-nitrosoglutathione is lower than 2.8+/-0.6 x 10(7)M(-1)s(-1). The conversion of the thiyl radical to its carbon-centred form at 10(3)s(-1) exceeds the formation of S-nitrosoglutathione when physiological concentrations of nitrogen monoxide are taken into account.

Details

Language :
English
ISSN :
0006-291X
Volume :
360
Issue :
1
Database :
MEDLINE
Journal :
Biochemical and biophysical research communications
Publication Type :
Academic Journal
Accession number :
17588542
Full Text :
https://doi.org/10.1016/j.bbrc.2007.06.008