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Synthesis of hyaluronic acid oligomers using Ph2SO/Tf2O-mediated glycosylations.

Authors :
Dinkelaar J
Codée JD
van den Bos LJ
Overkleeft HS
van der Marel GA
Source :
The Journal of organic chemistry [J Org Chem] 2007 Jul 20; Vol. 72 (15), pp. 5737-42. Date of Electronic Publication: 2007 Jun 22.
Publication Year :
2007

Abstract

The synthesis of hyaluronic acid (HA) oligomers using a stepwise glycosylation strategy is described. This method employs protected 1-hydroxyuronic acid and 1-phenylthio glucosamine donors, both of which are activated with the Ph2SO/Tf2O activator system.

Details

Language :
English
ISSN :
0022-3263
Volume :
72
Issue :
15
Database :
MEDLINE
Journal :
The Journal of organic chemistry
Publication Type :
Academic Journal
Accession number :
17585821
Full Text :
https://doi.org/10.1021/jo070704s