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The history of clozapine and its emergence in the US market: a review and analysis.
- Source :
-
History of psychiatry [Hist Psychiatry] 2007 Mar; Vol. 18 (1), pp. 39-60. - Publication Year :
- 2007
-
Abstract
- Clozapine is known as the first 'atypical' medication and is effective in people who have treatment-resistant schizophrenia. Its 1990 emergence in the USA was marked by considerable controversy over its high cost, due in large part to having been both the first new antipsychotic medication to come to market in over a decade and the need for comprehensive safety monitoring within a decentralized health system. This paper traces the history of clozapine's discovery and development in Europe, its part in the 1975 Finnish agranulocytosis scare, and its subsequent volatile emergence in the USA. Analyses examine peripheral forces at the time, particularly the influence of political, corporate, medical and societal forces which shaped its market course.
- Subjects :
- Antipsychotic Agents adverse effects
Antipsychotic Agents therapeutic use
Clozapine adverse effects
Clozapine therapeutic use
Drug Approval history
Finland
History, 20th Century
History, 21st Century
Humans
Schizophrenia drug therapy
United States
United States Food and Drug Administration history
Antipsychotic Agents history
Clozapine history
Psychiatry history
Schizophrenia history
Subjects
Details
- Language :
- English
- ISSN :
- 0957-154X
- Volume :
- 18
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- History of psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 17580753
- Full Text :
- https://doi.org/10.1177/0957154X07070335