Marked improvement with sildenafil in a patient with idiopathic pulmonary arterial hypertension unresponsive to beraprost and sarpogrelate.

Authors :: Kawano H
Sengyoku H
Satoh O
Urabe S
Koide Y
Yano K
Source :: Internal medicine (Tokyo, Japan) [Intern Med] 2007; Vol. 46 (12), pp. 893-8. Date of Electronic Publication: 2007 Jun 15.
Publication Year :: 2007
Abstract: We report a 16-year-old man with severe heart failure due to idiopathic pulmonary arterial hypertension (IPAH). The patient was initially treated with a combination of beraprost, a prostacyclin analog, and sarpogrelate, a serotonin receptor inhibitor. However, he was unresponsive to the treatment. We then changed the treatment to sildenafil, and his condition dramatically improved. Sildenafil has an immediate pulmonary vasodilator effect in patients already receiving vasodilators for IPAH.

Subjects :: Adolescent
Drug Therapy, Combination
Epoprostenol analogs & derivatives
Epoprostenol therapeutic use
Humans
Hypertension, Pulmonary diagnosis
Male
Purines therapeutic use
Serotonin Antagonists therapeutic use
Sildenafil Citrate
Succinates therapeutic use
Treatment Outcome
Hypertension, Pulmonary drug therapy
Piperazines therapeutic use
Sulfones therapeutic use
Vasodilator Agents therapeutic use

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