Back to Search
Start Over
A specialized nucleosome has a "point" to make.
- Source :
-
Cell [Cell] 2007 Jun 15; Vol. 129 (6), pp. 1047-9. - Publication Year :
- 2007
-
Abstract
- Three recent papers, including Mizuguchi et al. (2007) in this issue, show that the nonhistone protein Scm3 is required for the recruitment of the histone H3 variant Cse4 to centromeres in budding yeast. Scm3 forms a chromatin component with Cse4:histone H4 tetramers that appear to lack H2A/H2B histones. These studies provide key insights into the pathway that recruits Cse4 to centromeres and have important implications for other functions of chromatin.
- Subjects :
- Centromere ultrastructure
Chromatin chemistry
DNA Repair
DNA Replication
Models, Biological
Saccharomyces cerevisiae metabolism
Chromosomal Proteins, Non-Histone metabolism
Chromosomal Proteins, Non-Histone physiology
DNA-Binding Proteins metabolism
Histones metabolism
Nucleosomes metabolism
Saccharomyces cerevisiae Proteins metabolism
Saccharomyces cerevisiae Proteins physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0092-8674
- Volume :
- 129
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Cell
- Publication Type :
- Academic Journal
- Accession number :
- 17574019
- Full Text :
- https://doi.org/10.1016/j.cell.2007.05.054