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Physiological and behavioural effects of an intracerebroventricular injection of corticotropin releasing hormone in goats.
- Source :
-
Veterinary journal (London, England : 1997) [Vet J] 2008 Jul; Vol. 177 (1), pp. 116-23. Date of Electronic Publication: 2007 Jun 14. - Publication Year :
- 2008
-
Abstract
- This study investigated the effects of an intracerebroventricular (ICV) injection of corticotropin releasing hormone (CRH) on physiological and behavioural responses in goats. In Experiment 1, saline (control) or saline plus 25 microg of ovine CRH was injected into the third ventricle of castrated male goats. CRH increased plasma cortisol (Cor) levels markedly within 15 min, but had little effect on plasma glucose (Glu). Compared with saline injected goats, CRH decreased the total duration of lying behaviour but increased its frequency, and suppressed rumination and self-grooming. In Experiment 2, the effects of an intravenous (IV) injection of human adrenocorticotropic hormone (ACTH) (1-24) (0.1mg) were examined and an IV injection of saline was used as control. ACTH increased plasma Cor levels markedly, but did not change any behaviour compared with controls. It was concluded that CRH mediated the response of the hypothalamus-pituitary-adrenal (HPA) axis and behaviour following stress in goats, although the CRH-induced behavioural changes were independent of the HPA axis and seemed to be the result of direct action within the central nervous system.
- Subjects :
- Adrenocorticotropic Hormone administration & dosage
Adrenocorticotropic Hormone pharmacokinetics
Animals
Area Under Curve
Behavior, Animal physiology
Blood Glucose drug effects
Blood Glucose metabolism
Corticotropin-Releasing Hormone pharmacokinetics
Corticotropin-Releasing Hormone pharmacology
Hydrocortisone blood
Hypothalamo-Hypophyseal System drug effects
Hypothalamo-Hypophyseal System physiology
Male
Pituitary-Adrenal System drug effects
Pituitary-Adrenal System physiology
Random Allocation
Adrenocorticotropic Hormone pharmacology
Behavior, Animal drug effects
Corticotropin-Releasing Hormone administration & dosage
Goats physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1090-0233
- Volume :
- 177
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Veterinary journal (London, England : 1997)
- Publication Type :
- Academic Journal
- Accession number :
- 17572122
- Full Text :
- https://doi.org/10.1016/j.tvjl.2007.04.002