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[Promoting myelin repair in disorders such as multiple sclerosis and some types of leukodystrophy: current studies].
- Source :
-
Revue neurologique [Rev Neurol (Paris)] 2007 May; Vol. 163 (5), pp. 523-31. - Publication Year :
- 2007
-
Abstract
- Several ways of promoting myelin repair in myelin disorders such as multiple sclerosis and certain types of leukodystrophies are currently being investigated. Numerous studies suggest that it is possible to repair the central nervous system (CNS) by cell transplantation or by enhancing endogenous remyelination. Investigations in animal models indicate that cell therapy results in robust anatomical and functional recovery of acute myelin lesions. These models are also used to explore and validate the role of candidate molecules to stimulate endogenous remyelination by activating the myelin competent population or providing neuroprotection. However, in view of the heterogeneity of the lesion environment in MS, it seems more likely that cell therapy alone will not be able to contribute efficiently to the repair of the lesion. Further developments should indicate whether combining multiple approaches will be more powerful to achieve global myelin repair in the CNS than applying these strategies alone.
- Subjects :
- Axons drug effects
Axons pathology
Humans
Magnetic Resonance Imaging
Neuroimmunomodulation physiology
Olfactory Bulb drug effects
Olfactory Bulb pathology
Oligodendroglia drug effects
Oligodendroglia pathology
Regeneration drug effects
Stem Cells drug effects
Stem Cells pathology
Leukodystrophy, Metachromatic drug therapy
Leukodystrophy, Metachromatic pathology
Multiple Sclerosis drug therapy
Multiple Sclerosis pathology
Myelin Sheath drug effects
Myelin Sheath pathology
Neuroprotective Agents pharmacology
Neuroprotective Agents therapeutic use
Subjects
Details
- Language :
- French
- ISSN :
- 0035-3787
- Volume :
- 163
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Revue neurologique
- Publication Type :
- Academic Journal
- Accession number :
- 17571021
- Full Text :
- https://doi.org/10.1016/s0035-3787(07)90459-2