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A positron emission tomography study of 5-hydroxytryptamine-1A receptors in Alzheimer disease.
- Source :
-
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry [Am J Geriatr Psychiatry] 2007 Oct; Vol. 15 (10), pp. 888-98. Date of Electronic Publication: 2007 Jun 13. - Publication Year :
- 2007
-
Abstract
- Objective: The important role of serotonin-1A (5-hydroxytryptamine-1A [5-HT(1A)]) receptors in cognition, behavior, and drug response is increasingly being recognized. Postmortem studies suggest decreased 5-HT(1A) receptors in patients with Alzheimer disease (AD), but this has not been confirmed in vivo. Our primary objective was to assess the extent of 5-HT(1A) receptor losses in mild to moderate AD.<br />Methods: The authors examined 5-HT(1A) receptors in 10 patients with mild to moderate AD and 10 healthy volunteers with the same sex and similar age using positron emission tomography imaging with the selective 5-HT(1A) receptor radioligand, [(11)C]WAY-100635. Regions of interest (ROIs) were manually drawn on coregistered magnetic resonance images for the frontal, lateral temporal, medial temporal (MTC), parietal, and cerebellar cortices. Using the simplified reference tissue model, 5-HT(1A) binding potentials (BPs) were calculated relative to the cerebellum.<br />Results: After adjusting for partial volume effects, ROI analysis showed a significant group effect (AD versus comparison group) on BP. Analysis of between-subjects factors showed significantly decreased 5-HT(1A) BP in the right MTC, but not in the other ROIs.<br />Conclusion: Given the strategic role of these receptors, loss of right medial temporal 5-HT(1A) receptors might play an important role in AD symptomatology.
- Subjects :
- Aged
Alzheimer Disease diagnosis
Carbon Radioisotopes
Female
Functional Laterality physiology
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging statistics & numerical data
Male
Piperazines
Psychiatric Status Rating Scales
Pyridines
Severity of Illness Index
Temporal Lobe diagnostic imaging
Temporal Lobe metabolism
Alzheimer Disease diagnostic imaging
Alzheimer Disease metabolism
Cerebellar Cortex diagnostic imaging
Cerebellar Cortex metabolism
Cerebral Cortex diagnostic imaging
Cerebral Cortex metabolism
Positron-Emission Tomography statistics & numerical data
Receptor, Serotonin, 5-HT1A metabolism
Serotonin metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1064-7481
- Volume :
- 15
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 17567932
- Full Text :
- https://doi.org/10.1097/JGP.0b013e3180488325