Back to Search Start Over

A positron emission tomography study of 5-hydroxytryptamine-1A receptors in Alzheimer disease.

Authors :
Lanctôt KL
Hussey DF
Herrmann N
Black SE
Rusjan PM
Wilson AA
Houle S
Kozloff N
Verhoeff NP
Kapur S
Source :
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry [Am J Geriatr Psychiatry] 2007 Oct; Vol. 15 (10), pp. 888-98. Date of Electronic Publication: 2007 Jun 13.
Publication Year :
2007

Abstract

Objective: The important role of serotonin-1A (5-hydroxytryptamine-1A [5-HT(1A)]) receptors in cognition, behavior, and drug response is increasingly being recognized. Postmortem studies suggest decreased 5-HT(1A) receptors in patients with Alzheimer disease (AD), but this has not been confirmed in vivo. Our primary objective was to assess the extent of 5-HT(1A) receptor losses in mild to moderate AD.<br />Methods: The authors examined 5-HT(1A) receptors in 10 patients with mild to moderate AD and 10 healthy volunteers with the same sex and similar age using positron emission tomography imaging with the selective 5-HT(1A) receptor radioligand, [(11)C]WAY-100635. Regions of interest (ROIs) were manually drawn on coregistered magnetic resonance images for the frontal, lateral temporal, medial temporal (MTC), parietal, and cerebellar cortices. Using the simplified reference tissue model, 5-HT(1A) binding potentials (BPs) were calculated relative to the cerebellum.<br />Results: After adjusting for partial volume effects, ROI analysis showed a significant group effect (AD versus comparison group) on BP. Analysis of between-subjects factors showed significantly decreased 5-HT(1A) BP in the right MTC, but not in the other ROIs.<br />Conclusion: Given the strategic role of these receptors, loss of right medial temporal 5-HT(1A) receptors might play an important role in AD symptomatology.

Details

Language :
English
ISSN :
1064-7481
Volume :
15
Issue :
10
Database :
MEDLINE
Journal :
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Publication Type :
Academic Journal
Accession number :
17567932
Full Text :
https://doi.org/10.1097/JGP.0b013e3180488325