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Evaluation of dirlotapide for sustained weight loss in overweight Labrador retrievers.
- Source :
-
Journal of veterinary pharmacology and therapeutics [J Vet Pharmacol Ther] 2007 Aug; Vol. 30 Suppl 1, pp. 55-65. - Publication Year :
- 2007
-
Abstract
- The effects of dirlotapide on body weight (BW) reduction were investigated in overweight Labradors in two parallel-design studies. Study A involved 42 dogs randomized to 0.0, 0.025, 0.05, 0.1, 0.2 or 0.4 mg dirlotapide/kg/day orally for 4 weeks. Study B involved 72 dogs randomized to nine treatments: placebo (24 weeks); dirlotapide (24 weeks) followed by placebo (28 weeks); or dirlotapide (52 weeks); on diets containing 5%, 10% or 15% fat. Dirlotapide dose (initially 0.1 mg/kg) was adjusted monthly during 24-week weight-loss and subsequent 28-week weight-stabilization phases. Food was offered above maintenance energy requirements (MERx 1.1-1.2) based on initial BW. Body composition (body fat, lean tissue and bone mineral content) was monitored using dual-energy X-ray absorptiometry. After treatment, dogs that had received dirlotapide for 52 weeks were fed 90% of quantity consumed at week 52. In study A, BW and food intake decreased asymptotically with dose: mean weekly weight loss exceeded 1% at 0.1-0.4 mg/kg. In study B, dirlotapide resulted in significant mean weekly weight loss (>0.8%) and decreased food intake over 24 weeks compared with placebo (P = 0.0001) for all diets. Food restriction minimized post-treatment weight rebound. Dirlotapide administered daily to dogs for up to 52 weeks was clinically safe and resulted in sustained weight reduction.
- Subjects :
- Absorptiometry, Photon veterinary
Administration, Oral
Animals
Anti-Obesity Agents administration & dosage
Carbamates administration & dosage
Dog Diseases pathology
Dogs
Eating
Female
Indoles administration & dosage
Male
Pedigree
Treatment Outcome
Weight Loss
Anti-Obesity Agents therapeutic use
Carbamates therapeutic use
Dog Diseases drug therapy
Indoles therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0140-7783
- Volume :
- 30 Suppl 1
- Database :
- MEDLINE
- Journal :
- Journal of veterinary pharmacology and therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 17567515
- Full Text :
- https://doi.org/10.1111/j.1365-2885.2007.00855.x