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Hypoglycemia associated hospitalizations in a population with a high prevalence of non-insulin-dependent diabetes mellitus.
- Source :
-
Diabetes research and clinical practice [Diabetes Res Clin Pract] 1991 Nov; Vol. 14 (2), pp. 139-47. - Publication Year :
- 1991
-
Abstract
- In order to evaluate the rates, causes, and clinical features of hospitalizations associated with hypoglycemia in a population with a high prevalence of non-insulin-dependent diabetes mellitus (NIDDM), a retrospective analysis of medical records was conducted in a multi-hospital primary care system on the Navajo Indian Reservation. During an estimated 26,125 person-years of observation among diabetic patients, there were 126 hypoglycemia-associated admissions related to diabetes among 109 diabetic patients, yielding a hospitalization rate of 4.7 per 1000 person-years (95% CI 4.1-5.7). Using estimates of drug utilization based on a defined daily dose, hospitalization rates were 5.8 per 1000 PY (95% CI 4.4-7.6) for chlorpropamide, 16.0 per 1000 PY (95% CI 9.5-26.9) for glyburide, and 9.1 per 1000 PY (95% CI 6.9-11.9) for insulin. After stratification by age, the relative risk for hypoglycemia-associated hospitalization among patients prescribed glyburide compared to those prescribed chlorpropamide was 2.8 (95% CI 1.6-4.9). Hypoglycemia-associated hospitalizations were relatively common among patients with NIDDM, particularly among those treated with glyburide.
- Subjects :
- Arizona epidemiology
Hospitalization
Humans
Hypoglycemia chemically induced
Hypoglycemia mortality
New Mexico epidemiology
Prevalence
Retrospective Studies
Utah epidemiology
Chlorpropamide adverse effects
Diabetes Mellitus, Type 2 drug therapy
Diabetes Mellitus, Type 2 epidemiology
Glyburide adverse effects
Hypoglycemia epidemiology
Indians, North American
Insulin adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 0168-8227
- Volume :
- 14
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Diabetes research and clinical practice
- Publication Type :
- Academic Journal
- Accession number :
- 1756685
- Full Text :
- https://doi.org/10.1016/0168-8227(91)90120-3