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Synthesis of new (Nalpha-dipicolinoyl)-bis-L-valyl-L-phenylalanyl linear and macrocyclic bridged peptides as anti-inflammatory agents.
- Source :
-
Archiv der Pharmazie [Arch Pharm (Weinheim)] 2007 Jun; Vol. 340 (6), pp. 304-9. - Publication Year :
- 2007
-
Abstract
- In continuation to our search for new chiral macrocyclic peptide-based anti-inflammatories, the suggestion, synthesis, structure elucidation of some Nalpha-bis-dipicolinoyl amino acids, linear, tetra and cyclic (penta and octa)-bridged peptides 3-10, were realized herein. The newly synthesized compounds showed potent anti-inflammatory activity with low toxicity (LD50) comparable to indomethacin and diclofenac as reference anti-inflammatory drugs.
- Subjects :
- Animals
Anti-Inflammatory Agents, Non-Steroidal chemistry
Carrageenan administration & dosage
Carrageenan toxicity
Dipeptides chemistry
Hindlimb
Inflammation chemically induced
Inflammation prevention & control
Injections
Male
Molecular Structure
Peptides, Cyclic chemistry
Picolinic Acids chemistry
Rats
Anti-Inflammatory Agents, Non-Steroidal chemical synthesis
Anti-Inflammatory Agents, Non-Steroidal pharmacology
Dipeptides chemical synthesis
Dipeptides pharmacology
Peptides, Cyclic chemical synthesis
Peptides, Cyclic pharmacology
Picolinic Acids chemical synthesis
Picolinic Acids pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0365-6233
- Volume :
- 340
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Archiv der Pharmazie
- Publication Type :
- Academic Journal
- Accession number :
- 17562563
- Full Text :
- https://doi.org/10.1002/ardp.200600187