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Treatment response and colonic gene expression in patients with Crohn's disease.
- Source :
-
Scandinavian journal of gastroenterology [Scand J Gastroenterol] 2007 Jul; Vol. 42 (7), pp. 834-40. - Publication Year :
- 2007
-
Abstract
- Objective: Responses and adverse events to medication vary greatly among patients with Crohn's disease (CD). The aim of this study was to investigate whether global gene expression profiles could predict such responses and possible side effects.<br />Material and Methods: Tissue specimens from the descending colon were obtained from 32 CD patients (in 18 patients from areas without inflammation and in 14 patients from inflamed areas). Gene profiling was done using the Affymetrix Human Genome U133 Plus 2.0 GeneChip array. Hybridization data were analyzed with dChip software.<br />Results: There were no differentially expressed genes between six patients who responded well to azathioprine and four who did not. No differences were found between 12 patients with adverse events to azathioprine and 9 patients who tolerated this drug. Sixteen patients who were not glucocorticoid-dependent had no differentially expressed genes as compared with 15 glucocorticoid-dependent patients. Six patients who responded well to infliximab had only one differentially expressed gene as compared to four patients who did not.<br />Conclusions: DNA microarray analyses did not show differentially expressed genetic profiles from colonic mucosal cells obtained from groups of patients classified according to therapeutic criteria.
- Subjects :
- Adolescent
Adult
Azathioprine adverse effects
Cluster Analysis
Colon, Descending metabolism
Colonoscopy
Crohn Disease drug therapy
Crohn Disease metabolism
Female
Gene Expression Profiling
Glucocorticoids therapeutic use
Humans
Immunosuppressive Agents adverse effects
Intestinal Mucosa metabolism
Male
Middle Aged
Nucleic Acid Hybridization
Pharmacogenetics
Prognosis
Azathioprine therapeutic use
Crohn Disease genetics
Gene Expression
Immunosuppressive Agents therapeutic use
Oligonucleotide Array Sequence Analysis
Subjects
Details
- Language :
- English
- ISSN :
- 0036-5521
- Volume :
- 42
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Scandinavian journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 17558907
- Full Text :
- https://doi.org/10.1080/00365520601127166