Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates.

Authors :: Dalrymple A
Wild EJ
Joubert R
Sathasivam K
Björkqvist M
Petersén A
Jackson GS
Isaacs JD
Kristiansen M
Bates GP
Leavitt BR
Keir G
Ward M
Tabrizi SJ
Source :: Journal of proteome research [J Proteome Res] 2007 Jul; Vol. 6 (7), pp. 2833-40. Date of Electronic Publication: 2007 Jun 07.
Publication Year :: 2007
Abstract: Huntington's disease (HD) causes widespread CNS changes and systemic abnormalities including endocrine and immune dysfunction. HD biomarkers are needed to power clinical trials of potential treatments. We used multiplatform proteomic profiling to reveal plasma changes with HD progression. Proteins of interest were evaluated using immunoblotting and ELISA in plasma from 2 populations, CSF and R6/2 mice. The identified proteins demonstrate neuroinflammation in HD and warrant further investigation as possible biomarkers.

Subjects :: Animals
Biomarkers blood
Blotting, Western
Electrophoresis, Gel, Two-Dimensional
Encephalitis immunology
Enzyme-Linked Immunosorbent Assay
Humans
Huntington Disease immunology
Interleukin-6 blood
Mice
Protein Array Analysis
Blood Proteins analysis
Central Nervous System metabolism
Encephalitis blood
Huntington Disease blood
Proteomics

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