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Apoptotic cellular events for selenium compounds involved in cancer prevention.
- Source :
-
Journal of bioenergetics and biomembranes [J Bioenerg Biomembr] 2007 Feb; Vol. 39 (1), pp. 91-8. - Publication Year :
- 2007
-
Abstract
- Converging data from epidemiological, ecological, and clinical studies have shown that selenium (Se) can decrease the risk for some types of human cancers. Induction of apoptosis is considered an important cellular event that can account for the cancer preventive effects of Se. Prior to occurrence of apoptosis, Se compounds alter the expression and/or activities of signaling molecules, mitochondria-associated factors, transcriptional factors, tumor suppressor genes, and cellular reduced glutathione. Mechanistic studies have demonstrated that the methylselenol metabolite pool has many desirable attributes of chemoprevention, whereas the hydrogen selenide pool with excess of selenoprotein synthesis can lead to DNA single-strand breaks. To elucidate the effects of Se on cytotoxic events, it should be remembered that the chemical forms and the dose of Se, and the experimental system used, are determinants of its biological activities. This mini-review focuses on elucidation of the molecular mechanisms of cancer prevention by Se with the apoptotic approach.
- Subjects :
- Anticarcinogenic Agents pharmacology
Apoptosis drug effects
Humans
Methanol analogs & derivatives
Organometallic Compounds pharmacology
Organometallic Compounds therapeutic use
Organoselenium Compounds
Selenium pharmacology
Selenium Compounds pharmacology
Selenium Compounds therapeutic use
Selenoproteins biosynthesis
Anticarcinogenic Agents therapeutic use
Apoptosis physiology
DNA Breaks, Single-Stranded
Neoplasms prevention & control
Selenium therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0145-479X
- Volume :
- 39
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of bioenergetics and biomembranes
- Publication Type :
- Academic Journal
- Accession number :
- 17549643
- Full Text :
- https://doi.org/10.1007/s10863-006-9065-7