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An Hsp70 peptide initiates NK cell killing of leukemic blasts after stem cell transplantation.
- Source :
-
Leukemia research [Leuk Res] 2008 Apr; Vol. 32 (4), pp. 527-34. Date of Electronic Publication: 2007 May 31. - Publication Year :
- 2008
-
Abstract
- In contrast to solid tumors, leukemic blasts frequently present both Hsp70 and HLA-E on their cell surface and thereby present activating and inhibitory signals to CD94(+) NK cells. In the first 12 months after stem cell transplantation (SCT) CD94(+) NK cells clearly dominate over CD3(+)/CD16(-)/56(-) T and CD3(+)/CD16(+)/56(+) NK-like T cells. An incubation of post-SCT-derived peripheral blood lymphocytes with the Hsp70 peptide TKD and IL-15 enhances the cell surface density of CD56/CD94 and initiates the cytolytic activity of NK cells against Hsp70/HLA-E double-positive autologous and allogeneic leukemic blasts. Hsp70 was identified as the target structure for TKD-activated NK cells.
- Subjects :
- Antigens, CD metabolism
Cytotoxicity, Immunologic
Enzyme-Linked Immunosorbent Assay
Flow Cytometry
HLA Antigens physiology
Histocompatibility Antigens Class I physiology
Humans
Interleukin-15 metabolism
Leukemia immunology
Leukemia, Lymphocytic, Chronic, B-Cell immunology
Leukemia, Lymphocytic, Chronic, B-Cell pathology
Leukemia, Myelogenous, Chronic, BCR-ABL Positive immunology
Leukemia, Myelogenous, Chronic, BCR-ABL Positive pathology
Leukemia, Myeloid, Acute immunology
Leukemia, Myeloid, Acute pathology
Leukocytes, Mononuclear drug effects
Leukocytes, Mononuclear immunology
Leukocytes, Mononuclear metabolism
Middle Aged
Precursor Cell Lymphoblastic Leukemia-Lymphoma immunology
Precursor Cell Lymphoblastic Leukemia-Lymphoma pathology
Tumor Cells, Cultured
HLA-E Antigens
HSP70 Heat-Shock Proteins physiology
Killer Cells, Natural immunology
Leukemia pathology
Peptide Fragments physiology
Stem Cell Transplantation
Subjects
Details
- Language :
- English
- ISSN :
- 0145-2126
- Volume :
- 32
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Leukemia research
- Publication Type :
- Academic Journal
- Accession number :
- 17543383
- Full Text :
- https://doi.org/10.1016/j.leukres.2007.03.027