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Immunosuppressive lignans isolated from Saururus chinensis.
- Source :
-
Planta medica [Planta Med] 2007 Jun; Vol. 73 (7), pp. 674-8. Date of Electronic Publication: 2007 May 31. - Publication Year :
- 2007
-
Abstract
- Bioactivity-guided fractionation of Saururus chinensis (Saururaceae) using a lymphoproliferation assay led us to isolate 5 lignans (compounds 1 - 5). Compounds 1 - 5 were identified as sauchinone, (-)-saucerneol, saucerneol C, manassantin A, and manassantin B, respectively, by spectroscopic analyses. The immunosuppressive activities of the active compounds were evaluated using lymphoproliferation, mixed leukocyte response, and Th1/Th2 cytokine assays. The relative potency was in the order: manassantin A, B > (-)-saucerneol > saucerneol C > sauchinone.
- Subjects :
- Cell Proliferation drug effects
Cytokines metabolism
Humans
Immunosuppressive Agents administration & dosage
Immunosuppressive Agents therapeutic use
Lignans administration & dosage
Lignans pharmacology
Lignans therapeutic use
Lymphocyte Culture Test, Mixed
Plant Extracts administration & dosage
Plant Extracts therapeutic use
Immunosuppressive Agents pharmacology
Lymphocytes drug effects
Lymphocytes metabolism
Phytotherapy
Plant Extracts pharmacology
Saururaceae
Subjects
Details
- Language :
- English
- ISSN :
- 0032-0943
- Volume :
- 73
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Planta medica
- Publication Type :
- Academic Journal
- Accession number :
- 17538870
- Full Text :
- https://doi.org/10.1055/s-2007-981525