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Antiulcerogenic effects of two Maytenus species in laboratory animals.
- Source :
-
Journal of ethnopharmacology [J Ethnopharmacol] 1991 Aug; Vol. 34 (1), pp. 21-7. - Publication Year :
- 1991
-
Abstract
- Leaves of Maytenus species are commonly used in Brazil for the treatment of gastric ulcers, dyspepsias and other gastric problems. The present study evaluated the antiulcerogenic potential of a boiling water extract of equal parts of M. aquifolium and M. ilicifolia leaves against ulcer lesions induced by indomethacin and cold-restraint stress in rats. Ranitidine and cimetidine were used as reference drugs. The oral and intraperitoneal administration of the extract had a potent antiulcerogenic effect against both types of ulcers. The extract was shown to cause an increase in volume and pH of gastric juice of the animals with the pH effects comparable to those of cimetidine. The results tend to confirm the popular use of the plant.
- Subjects :
- Administration, Oral
Animals
Anti-Ulcer Agents analysis
Brazil
Cimetidine therapeutic use
Cold Temperature
Gastric Acid metabolism
Indomethacin toxicity
Injections, Intraperitoneal
Male
Plant Extracts administration & dosage
Plant Extracts therapeutic use
Rats
Rats, Inbred Strains
Restraint, Physical
Stomach Ulcer chemically induced
Stomach Ulcer etiology
Anti-Ulcer Agents pharmacology
Plants, Medicinal chemistry
Stomach Ulcer prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 0378-8741
- Volume :
- 34
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of ethnopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 1753784
- Full Text :
- https://doi.org/10.1016/0378-8741(91)90185-g