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Increased expression of h-prune is associated with tumor progression and poor survival in gastric cancer.
- Source :
-
Cancer science [Cancer Sci] 2007 Aug; Vol. 98 (8), pp. 1198-205. Date of Electronic Publication: 2007 May 25. - Publication Year :
- 2007
-
Abstract
- The human homolog of the Drosophila prune protein (from PRUNE, which encodes h-prune), which interacts with glycogen synthase kinase 3, promotes cellular motility. H-prune also interacts with nm23-H1, a suppressor of cancer metastasis. It has been reported that stimulation of cellular motility by h-prune is enhanced by its interaction with nm23-H1 in breast cancer cells. In the present study, we examined the expression of h-prune and nm23-H1 during tumor progression in gastric cancer (GC). PRUNE mRNA was overexpressed in 12 (32%) of 38 GC cases by quantitative reverse transcription-polymerase chain reaction. PRUNE mRNA levels correlated significantly with advanced T grade, N grade and tumor stage. Immunohistochemical analysis revealed that 43 (30%) of 143 GC cases were positive for h-prune, and h-prune-positive GC cases showed more advanced T grade, N grade and tumor stage than h-prune-negative GC cases. One hundred and twenty-four (87%) of 143 GC cases were positive for nm23-H1, and nm23-H1 was expressed in almost all (42 cases, 98%) h-prune-positive GC cases. Many GC cases positive for both h-prune and nm23-H1 showed more advanced T grade, N grade and tumor stage than other type GC cases. Patients with h-prune-positive GC had a significantly worse survival rate than patients with h-prune-negative GC. These findings indicate that overexpression of h-prune is associated with tumor progression and aggressiveness of GC. nm23-H1 may enhance motility of cancer cells by interacting with h-prune.
- Subjects :
- Aged
Disease Progression
Female
Humans
Immunohistochemistry
Male
NM23 Nucleoside Diphosphate Kinases
Nucleoside-Diphosphate Kinase metabolism
Phosphoric Monoester Hydrolases
Retrospective Studies
Reverse Transcriptase Polymerase Chain Reaction
Stomach Neoplasms mortality
Stomach Neoplasms pathology
Carrier Proteins metabolism
Stomach Neoplasms metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1347-9032
- Volume :
- 98
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Cancer science
- Publication Type :
- Academic Journal
- Accession number :
- 17532757
- Full Text :
- https://doi.org/10.1111/j.1349-7006.2007.00515.x