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Synthesis and evaluation of pyrazolo[3,4-b]pyridine CDK1 inhibitors as anti-tumor agents.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2007 Aug 01; Vol. 17 (15), pp. 4297-302. Date of Electronic Publication: 2007 May 16. - Publication Year :
- 2007
-
Abstract
- A series of 3,5-disubstituted pyrazolo[3,4-b]pyridine cyclin-dependent kinase (CDK) inhibitors was synthesized. These compounds showed potent and selective CDK inhibitory activities and inhibited in vitro cellular proliferation in cultured human tumor cells. Selected compounds were evaluated in an in vivo tumor xenograft model. The synthesis and biological evaluation of these pyrazolo[3,4-b]pyridines and related compounds are reported.
- Subjects :
- Antineoplastic Agents chemistry
Cells, Cultured
Humans
Protein Kinase Inhibitors chemistry
Pyrazoles chemistry
Pyridines chemistry
Antineoplastic Agents chemical synthesis
Antineoplastic Agents pharmacology
CDC2 Protein Kinase antagonists & inhibitors
Protein Kinase Inhibitors chemical synthesis
Protein Kinase Inhibitors pharmacology
Pyrazoles chemical synthesis
Pyrazoles pharmacology
Pyridines chemical synthesis
Pyridines pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 17
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 17532631
- Full Text :
- https://doi.org/10.1016/j.bmcl.2007.05.029