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Stem cell-associated genes are extremely poor prognostic factors for soft-tissue sarcoma patients.
- Source :
-
Oncogene [Oncogene] 2007 Nov 01; Vol. 26 (50), pp. 7170-4. Date of Electronic Publication: 2007 May 21. - Publication Year :
- 2007
-
Abstract
- Cancer stem cells can play an important role in tumorigenesis and tumor progression. However, it is still difficult to detect and isolate cancer stem cells. An alternative approach is to analyse stem cell-associated gene expression. We investigated the coexpression of three stem cell-associated genes, Hiwi, hTERT and survivin, by quantitative real-time-PCR in 104 primary soft-tissue sarcomas (STS). Multivariate Cox's proportional hazards regression analyses allowed correlating gene expression with overall survival for STS patients. Coexpression of all three stem cell-associated genes resulted in a significantly increased risk of tumor-related death. Importantly, tumors of patients with the poorest prognosis were of all four tumor stages, suggesting that their risk is based upon coexpression of stem cell-associated genes rather than on tumor stage.
- Subjects :
- Argonaute Proteins
Female
Humans
Inhibitor of Apoptosis Proteins
Male
Microtubule-Associated Proteins genetics
Neoplasm Proteins genetics
Prognosis
Proteins genetics
Sarcoma etiology
Survivin
Telomerase genetics
Neoplastic Stem Cells metabolism
Neoplastic Stem Cells pathology
Sarcoma genetics
Sarcoma pathology
Subjects
Details
- Language :
- English
- ISSN :
- 0950-9232
- Volume :
- 26
- Issue :
- 50
- Database :
- MEDLINE
- Journal :
- Oncogene
- Publication Type :
- Academic Journal
- Accession number :
- 17525744
- Full Text :
- https://doi.org/10.1038/sj.onc.1210530