Analytical interferences of drugs in the chemical examination of urinary protein.

Authors :: Scotti da Silva-Colombeli A
Falkenberg M
Source :: Clinical biochemistry [Clin Biochem] 2007 Sep; Vol. 40 (13-14), pp. 1074-6. Date of Electronic Publication: 2007 Apr 27.
Publication Year :: 2007
Abstract: Objectives: To evaluate the potential analytical interference of 24 drugs in the urinary protein.<br />Design and Methods: The analysis was done using Multistix 10SG and comparing the results of controls with urine samples supplemented with drugs.<br />Results: Positive interferences occurred with ciprofloxacin, quinine and chloroquine in supratherapeutical concentrations, while chloroquine interfered also in therapeutical concentration.<br />Conclusions: False proteinuria in test-strips can lead to erroneous interpretations with repercussion in clinical procedures and higher costs to the health system.

Subjects :: Chloroquine analysis
Ciprofloxacin analysis
Clinical Laboratory Techniques instrumentation
Clinical Laboratory Techniques methods
Humans
Quinine analysis
Reagent Strips
Reproducibility of Results
Sensitivity and Specificity
Pharmaceutical Preparations analysis
Proteinuria diagnosis
Proteinuria urine

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