Back to Search
Start Over
Trimetoquinol: bronchodilator effects in horses with heaves following aerosolised and oral administration.
- Source :
-
Equine veterinary journal [Equine Vet J] 2007 May; Vol. 39 (3), pp. 215-20. - Publication Year :
- 2007
-
Abstract
- Reason for Performing Study: The bronchodilator effects of trimetoquinol (TMQ) have been studied when administered i.v. or intratracheally, but not in an aerosolised form.<br />Objectives: To define the relationship between the therapeutic and adverse responses (therapeutic index) of TMQ when administered as an aerosol or by the oral route.<br />Methods: Increasing doses of TMQ were administered to horses with heaves as an aerosol and by the oral route. Dose ranged 100-1000 microg/horse for aerosolised TMQ and from 6-60 microg/kg bwt for the oral route. Airway and cardiac effects were assessed by measurement of maximal change in pleural pressure (deltaPplmax) and heart rate (HR), respectively. Side effects of sweating, agitation and muscle trembling were scored subjectively. Duration of action of aerosolised (1000 pg/horse) and oral (6-60 microg/kg bwt) TMQ was evaluated over 6 h.<br />Results: Aerosol administration of TMQ caused dose-dependent bronchodilation but did not change HR or cause other observable side effects. When 1000 microg/horse was administered via aerosol, TMQ produced a 2-phase bronchodilation; an immediate effect lasting up to 30 min and a second phase between 2 and 4 h. Oral TMQ was therapeutically ineffective.<br />Conclusion: Aerosol administration of TMQ is a safe and effective method of producing bronchodilation in horses.
- Subjects :
- Administration, Inhalation
Administration, Oral
Airway Obstruction drug therapy
Animals
Bronchodilator Agents adverse effects
Dose-Response Relationship, Drug
Female
Horses
Male
Recurrence
Treatment Outcome
Tretoquinol adverse effects
Airway Obstruction veterinary
Bronchodilator Agents therapeutic use
Horse Diseases drug therapy
Tretoquinol therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0425-1644
- Volume :
- 39
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Equine veterinary journal
- Publication Type :
- Academic Journal
- Accession number :
- 17520971
- Full Text :
- https://doi.org/10.2746/042516407x173334