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Further observations on the relationship between the FGFR4 Gly388Arg polymorphism and lung cancer prognosis.
- Source :
-
British journal of cancer [Br J Cancer] 2007 Jun 18; Vol. 96 (12), pp. 1904-7. Date of Electronic Publication: 2007 May 22. - Publication Year :
- 2007
-
Abstract
- The Gly388Arg polymorphism in the fibroblast growth factor receptor 4 (FGFR4) gene has been reported to influence prognosis in a wide variety of cancer types. To determine whether Gly388Arg is a marker for lung cancer prognosis, we genotyped 619 lung cancer patients with incident disease and examined the relationship between genotype and overall survival. While we employed a comprehensive set of statistical tests, including those sensitive to the detection of differences in early survival, our data provide little evidence to support the tenet that the FGFR4 Gly388Arg polymorphism is a clinically useful marker for lung cancer prognosis.
- Subjects :
- Arginine
Carcinoma, Non-Small-Cell Lung genetics
Carcinoma, Non-Small-Cell Lung mortality
Carcinoma, Non-Small-Cell Lung pathology
Carcinoma, Non-Small-Cell Lung therapy
Carcinoma, Small Cell genetics
Carcinoma, Small Cell pathology
Carcinoma, Small Cell therapy
Combined Modality Therapy
Glycine
Humans
Lung Neoplasms mortality
Lung Neoplasms pathology
Lung Neoplasms therapy
Middle Aged
Neoplasm Staging mortality
Polymorphism, Single Nucleotide
Prognosis
Survival Analysis
Amino Acid Substitution
Lung Neoplasms genetics
Receptor, Fibroblast Growth Factor, Type 4 genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0007-0920
- Volume :
- 96
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- British journal of cancer
- Publication Type :
- Academic Journal
- Accession number :
- 17519899
- Full Text :
- https://doi.org/10.1038/sj.bjc.6603816