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[Chemotherapy with cisplatin and 5-fluorouracil in inoperable brain metastases of bronchopulmonary cancers].
[Chemotherapy with cisplatin and 5-fluorouracil in inoperable brain metastases of bronchopulmonary cancers].
- Source :
-
Bulletin du cancer [Bull Cancer] 1991; Vol. 78 (9), pp. 831-7. - Publication Year :
- 1991
-
Abstract
- Chemotherapy is not a common treatment for cerebral metastases. The authors report results of combination chemotherapy with cisplatin (CDDP) and fluorouracil (5-FU). Sixteen men (age range 31-73 years) with brain metastases were treated with CDDP 20 mg/m2/day in continuous infusion for 5 days (d 1-5) and 5-FU 1 g/m2/day in continuous infusion for 4 days (d 1-4), and the treatment schedule repeated every 3 weeks. A brain computerized tomography after 2, 4 and 6 cycles was performed to assess efficacy. It was considered that complete response was achieved if no lesion was found on the CT scan, and partial response if at least half of the total volume had decreased. After 2 cycles, the response rate was therefore 8/16 (50%). Treatment toxicity was very mild with only 1 case of severe but reversible myelotoxicity (grade III). It is concluded that chemotherapy combination with CDDP and 5-FU is a useful treatment for brain metastasis of lung carcinoma.
- Subjects :
- Adult
Aged
Brain Neoplasms diagnostic imaging
Cisplatin administration & dosage
Drug Therapy, Combination
Echoencephalography
Fluorouracil administration & dosage
Humans
Male
Middle Aged
Tomography, X-Ray Computed
Brain Neoplasms drug therapy
Brain Neoplasms secondary
Cisplatin therapeutic use
Fluorouracil therapeutic use
Lung Neoplasms pathology
Subjects
Details
- Language :
- French
- ISSN :
- 0007-4551
- Volume :
- 78
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Bulletin du cancer
- Publication Type :
- Academic Journal
- Accession number :
- 1751834