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Growth hormone treatment and left ventricular dimensions in Turner syndrome.
- Source :
-
The Journal of pediatrics [J Pediatr] 2007 Jun; Vol. 150 (6), pp. 587-91. - Publication Year :
- 2007
-
Abstract
- Objective: To determine whether cardiac dimensions were different in girls with Turner syndrome (TS) who received growth hormone (GH) compared with those who did not receive GH.<br />Study Design: This retrospective, cross-sectional study analyzed echocardiograms in 86 females with TS divided into GH-treated (n = 67) and untreated (n = 19) groups. The subjects all participated in the National Institutes of Health protocol between 2001 and 2006.<br />Results: The average age was 16.2 years (range, 10 to 25 years), and average duration of GH treatment was 4.4 years (range, 1 to 14 years). The GH-treated group was taller by approximately 7 cm (P = .004), but cardiac dimensions normalized to body surface area (BSA), including septal and posterior wall thickness and left ventricular (LV) mass and internal diameters, did not differ significantly between the 2 groups. The fractional shortening index was similar in the 2 groups. Multiple regression analyses indicated that BSA, but not duration of GH treatment, predicted LV dimensions in girls with TS.<br />Conclusions: GH treatment of girls with TS increases stature but does not disproportionately affect cardiac dimensions.
- Subjects :
- Adolescent
Adult
Body Surface Area
Child
Cross-Sectional Studies
Echocardiography, Doppler
Female
Heart Ventricles diagnostic imaging
Human Growth Hormone therapeutic use
Humans
Regression Analysis
Turner Syndrome physiopathology
Growth Hormone therapeutic use
Heart drug effects
Heart Ventricles drug effects
Human Growth Hormone pharmacology
Turner Syndrome diagnostic imaging
Turner Syndrome drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6833
- Volume :
- 150
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The Journal of pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 17517238
- Full Text :
- https://doi.org/10.1016/j.jpeds.2007.02.009