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Fenugreek seeds modulate 1,2-dimethylhydrazine-induced hepatic oxidative stress during colon carcinogenesis.
- Source :
-
The Italian journal of biochemistry [Ital J Biochem] 2007 Mar; Vol. 56 (1), pp. 28-34. - Publication Year :
- 2007
-
Abstract
- 1,2-dimethylhydrazine (DMH) is a colon carcinogen which undergoes oxidative metabolism in the liver. We have investigated the modulatory effect of fenugreek seeds (a spice) on colon tumor incidence as well as hepatic lipid peroxidation (LPO) and antioxidant status during DMH-induced colon carcinogenesis in male Wistar rats. In DMH treated rats, 100% colon tumor incidence was accompanied by enhanced LPO and a decrease in reduced glutathione (GSH) content as well as a fall in glutathione peroxidase (GPx), glutathione S-transferase (GST), superoxide dismutase (SOD) and catalase (CAT) activities. Inclusion of fenugreek seed powder in the diet of DMH treated rats reduced the colon tumor incidence to 16.6%, decreased the LPO and increased the activities of GPx, GST, SOD and CAT in the liver. We report that fenugreek modulates DMH-induced hepatic oxidative stressduring colon cancer
- Subjects :
- 1,2-Dimethylhydrazine
Animals
Catalase metabolism
Chemical and Drug Induced Liver Injury
Colonic Neoplasms chemically induced
Liver drug effects
Liver enzymology
Male
Rats
Rats, Wistar
Superoxide Dismutase metabolism
Anticarcinogenic Agents therapeutic use
Antioxidants therapeutic use
Colonic Neoplasms drug therapy
Liver Diseases drug therapy
Oxidative Stress drug effects
Phytotherapy
Seeds
Trigonella chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0021-2938
- Volume :
- 56
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Italian journal of biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 17511351