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Prevalence of primary HIV-1 drug resistance in pregnant women and in newly diagnosed adults at Tijuana General Hospital, Baja California, Mexico.
- Source :
-
International journal of STD & AIDS [Int J STD AIDS] 2007 Apr; Vol. 18 (4), pp. 235-8. - Publication Year :
- 2007
-
Abstract
- At Tijuana General Hospital, between March 2003 and June 2005, pregnant women and other adults, recently identified as HIV infected, antiretroviral naïve, were enrolled to examine the prevalence of primary HIV drug resistance. All subjects had the Calypte HIV-1 BED Incidence enzyme immunoassay test to identify recent infection. Genotypic analysis of HIV-1 protease and reverse transcriptase regions in plasma was performed. Forty-six subjects participated, eight (17%) men, 38 (83%) women. Ten (22%) subjects were classified as having recent HIV infection. HIV genotype was performed in 41 subjects. One subject (2.5%) had a major mutation in the reverse transcriptase region (K219Q) conferring zidovudine resistance, one had a minor mutation at V118I (2.5%) and two subjects (5%) had minor mutation (V179D) associated with non-nucleoside reverse transcriptase inhibitor resistance. There were no major protease inhibitor-associated mutations but minor mutations were common. The prevalence of primary HIV drug resistance in Baja California is low.
- Subjects :
- Adult
Cross-Sectional Studies
DNA Mutational Analysis
Female
Genotype
HIV Infections drug therapy
HIV Infections genetics
HIV-1 genetics
Hospitals, General
Humans
Male
Mexico epidemiology
Outpatient Clinics, Hospital
Pregnancy
Pregnancy Complications, Infectious drug therapy
Pregnancy Complications, Infectious genetics
Drug Resistance, Multiple, Viral genetics
HIV Infections epidemiology
HIV-1 drug effects
Pregnancy Complications, Infectious epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 0956-4624
- Volume :
- 18
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- International journal of STD & AIDS
- Publication Type :
- Academic Journal
- Accession number :
- 17509172
- Full Text :
- https://doi.org/10.1258/095646207780658962