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The kappa-opioid receptor agonist U-69593 prevents cocaine-induced phosphorylation of DARPP-32 at Thr(34) in the rat brain.
- Source :
-
Brain research bulletin [Brain Res Bull] 2007 Jun 15; Vol. 73 (1-3), pp. 34-9. Date of Electronic Publication: 2007 Feb 20. - Publication Year :
- 2007
-
Abstract
- DARPP-32 (dopamine- and cAMP-regulated phosphoprotein) is a potent endogenous inhibitor of protein phosphatase-1, which plays an important role in dopaminergic transmission. A large body of evidence supports the key role of DARPP-32-dependent signalling in mediating the actions of multiple drugs of abuse, including cocaine, which, when acutely administered, increases the Thr(34) phosphorylation of DARPP-32 in the striatal and cortical areas. In this study, we have examined the contribution of the kappa opioid system to the regulation of DARPP-32 phosphorylation at Thr(34), following acute cocaine administration, in selected rat brain areas. Results showed that a single injection of cocaine induces a significant increase in DARPP-32 phosphorylation at Thr(34) in the hippocampus, caudate putamen and prefrontal cortex. In addition, pretreatment with the kappa opioid receptor agonist U-69593 prevented cocaine effects in all the investigated areas. These data could be considered consistent with the ability of kappa opioid agonists to attenuate many behavioural and neurochemical effects of cocaine.
- Subjects :
- Analgesics administration & dosage
Animals
Benzeneacetamides administration & dosage
Blotting, Western
Caudate Nucleus drug effects
Caudate Nucleus physiology
Cocaine pharmacology
Hippocampus drug effects
Hippocampus physiology
Injections
Male
Phosphorylation drug effects
Prefrontal Cortex drug effects
Prefrontal Cortex physiology
Putamen drug effects
Putamen physiology
Pyrrolidines administration & dosage
Rats
Rats, Sprague-Dawley
Analgesics pharmacology
Benzeneacetamides pharmacology
Brain Chemistry drug effects
Cocaine antagonists & inhibitors
Dopamine and cAMP-Regulated Phosphoprotein 32 metabolism
Pyrrolidines pharmacology
Receptors, Opioid, kappa agonists
Threonine metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0361-9230
- Volume :
- 73
- Issue :
- 1-3
- Database :
- MEDLINE
- Journal :
- Brain research bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 17499634
- Full Text :
- https://doi.org/10.1016/j.brainresbull.2007.01.014